Endothelial Dysfunction and LOX-1
نویسندگان
چکیده
منابع مشابه
Linking LOX-1 and arginase II through mitochondria: a novel paradigm in endothelial dysfunction.
Dysfunction Linking LOX-1 and Arginase II Through Mitochondria: A Novel Paradigm in Endothelial Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2014 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/CIRCRESAHA.114.30455
متن کاملInteraction of carbamylated LDL with LOX-1 in the induction of endothelial dysfunction and atherosclerosis.
Urea is a normal component of human blood plasma, but it is not inert. Urea-derived cyanate modification of LDL-cholesterol, known as LDL carbamylation, has been discussed for more than a decade. Recent studies have linked LDL carbamylation to atherosclerosis in uraemic patients and animals with chronic kidney disease (CKD). – 4 More broadly, protein carbamylation has been linked with atheroscl...
متن کاملEndothelial dysfunction and LOX-1: forty years from muscle to endothelium.
Discovery of a new function of vascular endothelium has opened new horizons in the research field of vascular biology. Today, we cannot talk about vascular diseases without endothelial function. I am happy to have participated in the development of this field in those days. In 1963, after graduating from the medical school at the University of Tokyo and finishing my internship, I entered the la...
متن کاملEGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling.
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), originally identified as the major receptor for oxidized low-density lipoprotein (oxLDL) in endothelial cells, plays a major role in the pathology of vascular diseases. Green tea consumption is associated with reduced cardiovascular mortality in some epidemiological studies. In the present study, we hypothesized that the most abun...
متن کاملMembrane Cholesterol Modulates LOX-1 Shedding in Endothelial Cells
The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor responsible for ox-LDL recognition, binding and internalization, which is up-regulated during atherogenesis. Its activation triggers endothelium dysfunction and induces inflammation. A soluble form of LOX-1 has been identified in the human blood and its presence considered a biomarker of cardiovascular d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2003
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000071523.67730.5f